Test Catalog

Test ID: TOXO    
Toxoplasma Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

Aids in the identification of Toxoplasma gondii infection

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Immunohistochemical staining for Toxoplasma gondii can help identify the organisms in the cytoplasm of infected cells. T gondii is a sporozoan that lives as an intracellular parasite in various tissues of vertebrates. T gondii is transmitted via raw or undercooked meat, contaminated soil, or by direct contact. Pregnant women and immunosuppressed patients are at highest risk for infection.

Interpretation Provides information to assist in interpretation of the test results

This test includes only technical performance of the stain (no pathologist interpretation is performed). Mayo Clinic cannot provide an interpretation of tech only stains outside the context of a pathology consultation. If an interpretation is needed, refer to PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case. All material associated with the case is required. Additional specific stains may be requested as part of the pathology consultation, and will be performed as necessary at the discretion of the Mayo pathologist.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Andres TL, Dorman SA, Winn W Jr., et al: Immunohistochemical demonstration of Toxoplasma gondii. Am J Clin Pathol 1981;75(3):431-434

2. Arnold SJ, Kinney MC, McCormick MS, et al: Disseminated toxoplasmosis. Unusual presentations in the immuinocompromised host. Arch Pathol Lab Med 1997;121(8):869-873

3. Held TK, Kruger D, Switala AR, et al: Diagnosis of toxoplasmosis in bone marrow transplant recipients: comparison of PCR-based results and immunohistochemistry. Bone Marrow Transplant 2000;25(12):1257-1262