TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: FFTRP    
Trofile Co-Receptor Tropism Assay

Useful For Suggests clinical disorders or settings where the test may be helpful

To determine the co-receptor tropism (CCR5, CXCR4, or dual/mixed) of a patient's HIV-1 strain for selection of CCR5 co-receptor antagonist therapy, when a patient's HIV-1 viral load is > or = 1,000 copies/mL. 

Interpretation Provides information to assist in interpretation of the test results

CCR5 Tropic (R5) HIV-1

Virus uses CCR5 to enter CD4+ cells.

 

CXCR4 Tropic (X4) HIV-1

Virus uses CXCR4 to enter CD4+ cells

 

DUAL/MIXED Tropic (D/M) HIV-1

Dual-tropic viruses can use either CCR5 or CXCR4 to enter CD4+ cells. Mixed-tropic populations contain viruses with two or more tropisms.

 

Non-reportable

Co-receptor tropism could not be determined by the Trofile assay. Common causes of a non-reportable result are viral load <1,000 copies/mL, reduced viral fitness, or compromised sample collection/handling.