Test Catalog

Test ID: RASFP    
RAS/RAF Targeted Gene Panel by Next-Generation Sequencing, Tumor

Useful For Suggests clinical disorders or settings where the test may be helpful

Identifying tumors that may respond to targeted therapies by assessing multiple gene targets simultaneously

 

Identifying mutations that may help determine prognosis for patients with solid tumors

 

Identifying specific mutations within genes known to be associated with response or resistance to specific cancer therapies

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This extended RAS/RAF panel test uses targeted next-generation sequencing to evaluate for somatic mutations within the BRAF (exons 11 and 15), HRAS (exons 2 and 3), NRAS (exons 2, 3, 4), and KRAS (exons 2, 3, 4) genes. This includes, but is not limited to, the testing of somatic mutations in KRAS codons 12, 13, 59, 61, 117, 146; NRAS codons 12, 13, 59, 61,146; HRAS codons 12, 13, 61; and BRAF codons 594, 596, 600. See Targeted Gene Regions Interrogated by RAS/RAF Gene Panel in Special Instructions for details regarding the targeted gene regions identified by this test.

 

Of note, this test is performed to evaluate for somatic mutations within tumor samples. This test does not assess for germline alterations within the genes listed.

Highlights

This test provides evaluation of BRAF (including V600), HRAS, NRAS (includes codons 12, 13, 59, 61, and 146), and KRAS (includes codons 12, 13, 59, 61, 117, and 146) genes for somatic mutations.

Additional Tests Lists tests that are always performed, at an additional charge, with the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
SLIRVSlide Review in MGNoYes

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

When this test is ordered, slide review will always be performed at an additional charge.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR)-Based Next Generation Sequencing

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

RAS/RAF Panel, Tumor

Aliases Lists additional common names for a test, as an aid in searching

Tumor panel
Oncology panel
NRAS
KRAS
HRAS
BRAF
Next Gen Sequencing Test
NGS
Colon cancer
Colorectal cancer