Test Catalog

Test ID: CH8    
Chromogenic Factor VIII Activity Assay, Plasma

Useful For Suggests clinical disorders or settings where the test may be helpful

Monitoring coagulation factor replacement therapy of selected extended half-life coagulation factor replacements


Aiding in the diagnosis of hemophilia A using a 2-stage assay, especially when the 1-stage assay was normal

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This assay is indicated in situations where there is a clinical suspicion of hemophilia A diagnosis, but the 1-stage Factor VIII assay is normal. However, recent guidelines also recommend this assay be performed in addition to the 1-stage assay in the initial workup of hemophilia A.


Testing for autoantibodies to FVIII in the presence of a low FVIII activity may be clinically indicated. For adding on FVIII inhibitor, contact Mayo Clinic Laboratories within 7 days to assess if adequate plasma sample is available.


Coagulation testing is highly complex, often requiring the performance of multiple assays and correlation with clinical information. For that reason, we recommend requesting a coagulation consultation.


See Hemophilia Testing Algorithm in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test


NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Chromogenic FVIII, P

Aliases Lists additional common names for a test, as an aid in searching

Factor 8
Factor VIII
Afstyla (rFVIII-SC)
Eloctate (rFVIII-Fc)
Kovaltry Antihemophilic Factor (Recombinant)
Nuwiq (simoctocog alfa)
Long Acting glycoPEGylated
Extend Half-life
Antihemophilic Factor (Recombinant), Single Chain
Antihemophilic Factor (Recombinant), Fc Fusion Protein
Antihemophilic Factor (Recombinant), PEGylated
Antihemophilic Factor (Recombinant)
Adynovate (octogog alfa pegol)