TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: SERU    
Serotonin, 24 Hour, Urine

Specimen Type Describes the specimen type validated for testing

Urine

Additional Testing Requirements

First-line testing for the diagnosis of carcinoid tumors with symptoms suggestive of carcinoid syndrome consists of urinary serotonin (SERU / Serotonin, 24 Hour, Urine), urinary 5-HIAA (HIAA / 5-Hydroxyindoleacetic Acid [5-HIAA], 24 Hour, Urine), and serum chromogranin A (CGAK / Chromogranin A, Serum).

Necessary Information

24-Hour volume is required.

Specimen Required Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Patient Preparation:

1. Patients should not eat avocados, bananas, butternuts, cantaloupe, dates, eggplant, grapefruit, hickory nuts, honeydew melon, kiwifruit, melon, nuts, pecans, pineapple, plantains, plums, tomatoes, or walnuts, which are high in serotonin for 48 hours before and during collection.

2. Patient should be off of medications that may elevate urine serotonin concentration including lithium, monoamine oxidase-inhibitors, methyldopa, morphine, and reserpine. Patient should also be off of selective serotonin reuptake inhibitors (eg, PROZAC) that can lead to depletion of platelet serotonin levels and result in false-negative urine serotonin tests.

3. Patient should avoid heavy nicotine consumption during the 24-hr collection period.

Container/Tube: Plastic, 10-mL urine tube (T068)

Specimen Volume: 5 mL

Collection Instructions:

1.  Add 25 mL of 50% acetic acid as preservative at start of collection.

2. Collect urine for 24-hours.

3. Refrigerate specimen during collection.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Forms

Urine Preservative Collection Options

Ambient

OK

Refrigerate

Preferred

Frozen

OK

50% Acetic Acid

Preferred

Boric Acid

No

Diazolidinyl Urea

No

6M Hydrochloric Acid

No

6M Nitric Acid

OK

Sodium Carbonate

No

Thymol

No

Toluene

OK

Specimen Minimum Volume Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory

2.5 mL

Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected

Gross hemolysis OK

Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen TypeTemperatureTimeSpecial Container
UrineRefrigerated (preferred)28 days
 Frozen 28 days
 Ambient 48 hours